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    您的位置:首頁 > 萬方期刊網 > 論文分類> 瑞舒伐他汀與氟伐他汀治療老年高脂血癥患者的臨床療效

    瑞舒伐他汀與氟伐他汀治療老年高脂血癥患者的臨床療效

    來源:萬方期刊網  時間:2018-04-16 11:26:32  點擊:

      (江蘇省揚州五臺山醫院;江蘇揚州 225003)

      【摘要】目的:觀察且比較在老年高脂血癥患者治療中予以瑞舒伐他汀、氟伐他汀2種藥物的療效。方法:選取本院住院和門診在2014年9月至2016年9月間所收治的老年高脂血癥患者共86例作為臨床對象,隨機分成對照組、觀察組。對照組予以氟伐他汀進行治療,觀察組予以瑞舒伐他汀進行治療,觀察與比較2組的臨床療效。結果:在實施不同藥物治療后,觀察組的療效比對照組高。經統計學分析,存在著P<0.05的顯著差異。結論:對于老年高脂血癥患者來說,予以瑞舒伐他汀與氟伐他汀2種藥物都對病情可以改善,但是瑞舒伐他汀的效果更為明顯,可以在臨床上予以廣泛的推廣。

      【關鍵詞】瑞舒伐他汀;氟伐他汀;老年高脂血癥;療效

      TG或是LDL—C指標的升高都會致使缺血性腦卒中或是冠心病產生,并且為危險因素,具有獨立性,所以對于異常血脂予以預防務必在早期引起注意,經循證醫學的研究已經證實,運用他汀類臨床藥物能夠將心血管疾病在臨床上的致死率或是產生率降低[1]。本次研究選取本院住院和門診于2014年9月至2016年9月間所收治的老年高脂血癥患者共86例作為臨床對象,分別予以瑞舒伐他汀、氟伐他汀藥物進行治療,獲取了顯著的療效結果,總結報告見下文。

      1.資料與方法

      1.1 一般資料

      選取本院住院和門診在2014年9月至2016年9月間所收治的老年高脂血癥患者共86例作為臨床資料,隨機分成對照組、觀察組,每組有43例患者。所有患者皆是在知情的狀況下參與本次研究,且已經簽署了知情同意書。在對照組中有23例為男性、20例為女性,其平均年齡約(75.4±7.5)歲;在觀察組中有24例為男性、19例為女性,其平均年齡約(73.4±8.7)歲。比較兩組臨床患者的一般資料(即年齡以及性別等),不存在顯著性差異,P>0.05,在統計學中具有一定的可比性。

      選入的標準:86例患者在予以本治療之前的2w之內沒有服用相關調脂類的藥物,與NCEP—ATPⅢ中冠心病的危險等級相關標準符合。

      排除標準:將甲狀腺功能產生減退的患者,患有腎病綜合征的患者,將異常肝功能的患者,將存在嚴重性腎功能不全的患者,或是合并有對其他調脂類藥物使用的患者等一律排除在外[2]。

      1.2 方法

      所有患者予以常規性治療,其中對照組予以氟伐他汀(為北京諾華制藥有限公司所生產,國藥準字號:H20090179)進行治療,服用的劑量是:20至40mg/次,且1次/d,確保在晚餐或是睡前進行吞服;觀察組予以瑞舒伐他汀(為正大天晴公司所生產,國藥準字號:H20080669)進行治療,口服劑量是:5至20mg/次,且1次/d,初始劑量應該以小劑量為主,依照患者的病情對劑量做以調整,需要于進食或是空腹狀態將其服下。所有患者持續8w用藥治療[3]。

      1.3 統計學分析

      本次臨床分析的數據由SPSS19.0軟件完成相關處理,使用(±s)去表示臨床中計量資料,實施t檢驗。比較兩組間的差異,若P<0.05則表示該差異在統計學中具有分析意義。

      2.結果

      比較2組的臨床指標水平:在予以8w的藥物治療之后,如表1所示,從數據中可知,觀察組的TC與LDL—C指標的水平明顯比對照組低,具有更高的降低效果。經統計學分析,組間差異比較顯著,且P<0.05,在統計學中具有分析意義。

      表1 比較2組的臨床指標水平

      3.討論

      經臨床上流行以及基礎性研究的證實,患者血脂異常成為動脈粥樣硬化或是冠心病病發的關鍵且危險因素,近些年,在國際上經多中心以且大規模的實踐研究已經表明:運用他汀類臨床藥物予以相關調脂的臨床治療,是心腦血管基礎疾病得以防治的重要對策及方法[4]。在治療中此類藥物對于高危類患者的高脂血癥予以改善,將冠狀脈不良事件或是手術以及卒中等產生率予以降低,是對療效的一種肯定。本次研究,對所選患者予以瑞舒伐他汀以及氟伐他汀藥物,其中瑞舒伐他汀在冠心病和心絞痛以及心律不齊多種疾病治療中具有理想的效果,屬于純中藥制劑。此外,對于血脂異常的治療效果也比較好。在降脂措施不能獲取理想效果下,可以優先選取本藥品;而氟伐他汀同樣可以在原發性高脂血癥以及血脂異常中進行應用,對于耐藥性較強或是有需要的患者,可以對2種藥物的使用劑量進行合理化調整[5]。其中觀察組予以瑞舒伐他汀進行治療,對照組予以氟伐他汀進行治療。結果顯示:觀察組臨床效果好于對照組,即:予以8w治療,觀察組TC(3.31±0.47)mmol/L,LDL—C(1.70±0.40)mmol/L;將臨床指標的水平顯著降低,且經統計學分析,存在著顯著的差異,即P<0.05,將統計學中的分析價值提高,該結果與有關文獻的研究報道相同,證實:在老年高脂血癥患者實施的治療中,可以予以以上2種藥物,但是瑞舒伐他汀的療效更加顯著。

      綜上所述,對于老年高脂血癥患者來說,選取瑞舒伐他汀以及氟伐他汀藥物進行治療,在病情上都可以獲得改善,但是瑞舒伐他汀對TC以及LDL—C指標降低作用更加明顯。基于該種藥物在應用中存在的優勢,可以在臨床上展開普及及推廣性應用。

      參考文獻:

      [1] 國希云,李曉英,鄧嫻等.瑞舒伐他汀與阿托伐他汀治療老年高脂血癥患者臨床療效的比較[J].中華老年心腦血管病雜志,2014(6):605-607.

      [2] 馬罡.瑞舒伐他汀對老年高脂血癥患者的藥效研究[J].醫學信息,2015(25):280-280.

      [3] 楊迎東.瑞舒伐他汀與阿托伐他汀對老年高脂血癥有效性、安全性及經濟性對比[J].中國現代藥物應用,2016,10(11):160-161.

      [4] 劉蓉昕.瑞舒伐他汀聯合西洛他唑治療老年高脂血癥的療效觀察[J].中國醫藥指南,2013(19):60-60.

      [5] 韓笑.瑞舒伐他汀合西洛他唑治療老年高脂血癥43例臨床療效觀察[J]. 中國民族民間醫藥,2014,23(01):89-89.

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