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    您的位置:首頁 > 萬方期刊網 > 論文分類> 肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三合一檢測臨床意義

    肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三合一檢測臨床意義

    來源:萬方期刊網  時間:2018-04-16 11:28:31  點擊:

      溫州市蒼南縣第三人民醫院 檢驗科、郵編325804

      【摘要】目的 分析肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三合一檢測的臨床意義。方法 選擇我院2015年1月至2017年1月收治的急性心肌梗死患者84例做為實驗組,選擇同期接受體檢的健康人員資料84例做為對照組。分別對兩組患者的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標進行評定并做對比。結果 實驗組的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標均高于對照組,其肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標檢測陽性結果概率也均高于對照組,且比較結果均具有統計學意義(P<0.05)。結論 肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標的提高是診斷心肌梗死疾病的重要指標,臨床可將以上三項指標作為心肌梗死快速診斷的依據。

      【關鍵詞】心肌梗死;肌鈣蛋白I;肌紅蛋白;肌酸激酶同工酶

      急性心肌梗死是臨床常見的心腦血管疾病,病情控制不及時患者會出現心源性休克貨心律失常等并發癥,嚴重者可直接導致死亡[1]。心肌酶譜是診斷心肌梗死的重要依據,其肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶由于高靈敏度目前已成為臨床檢測心肌梗死的標志物[2]。因此,及早診斷并對患者介入治療是提高心肌梗死臨床療效、降低病死率的關鍵因素。本次研究的主要目的在于分析肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三合一檢測的臨床意義,現有報告如下。

      1. 資料與方法

      1.1 一般資料

      選擇我院2015年1月至2017年1月收治的急性心肌梗死患者84例做為實驗組,所選患者均符合文獻診斷標準[3],同期接受體檢的健康人員資料84例做為對照組。其中,實驗組男45例,女39例,年齡38-82歲,平均年齡(51.3±3.5)歲;心肌梗死發病時間1-18h,平均發病時間(4.1±0.6)h。對照組中男43例,女41例,年齡40-84歲,平均年齡(55.7±1.5)歲。經統計學資料分析,兩組患者在年齡、性別等一般資料上無明顯差異(P>0.05),具有可比性。

      1.2 治療方法

      在實驗組入院一天后清晨,空腹、平穩狀態下抽取患者靜脈血液5ml,使用醫院現有自動生化分析儀采用發光法、速率法以及免疫比濁法對兩組患者的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標的水平進行測定,且比較測定結果。

      1.3 觀察指標

      分別對兩組研究對象的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標水平進行比較,以及三項指標檢測陽性率評定比較。

      1.4 評測標準

      肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶分別達到0.04ng/ml、70ng/ml、25U/L以上則評定為陽性結果[4]。

      1.5 統計學方法

      研究數據采用SPSS19.0統計學軟件進行分析處理,計量資料采用均數±標準差(`x±s)表示,t檢驗;計數資料采用百分率(%)表示,x?檢驗。以P<0.05表示差異具有統計學意義。

      2. 結果

      2.1 兩組研究對象的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶比較結果

      實驗組的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標均高于對照組,且比較結果具有統計學意義(P<0.05);詳情見表1。

      表1 肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶比較結果

      3 討論

      診斷急性心肌梗死的重要指標即為人體的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標。尤其是肌鈣蛋白I在心肌細胞的存在,它標志著心肌梗死疾病的出現[5]。人體在正常生理水平條件下,其三項指標的實際含量極低。而當心肌細胞壞死時,則會導致細胞內的肌鈣蛋白釋放于人體的血液,進而導致血肌鈣蛋白的濃度增高,提示心肌梗死病理的發生。傳統心肌梗死的診斷方法主要是依靠心電圖和血清的升高來確診,它的缺點是只能檢驗典型的病例。

      本次實驗以我院2015年1月至2017年1月收治的急性心肌梗死患者84例做為實驗組,以及同期接受體檢的健康人員資料84例做為對照組。分別對兩組患者的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標進行評定并做對比。實驗結果顯示,實驗組的肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標也均高于對照組,其肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標檢測陽性結果概率均高于對照組,且比較結果均具有統計學意義(P<0.05)。綜上,肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三項指標的提高是診斷心肌梗死疾病的重要指標,臨床可將以上三項指標作為心肌梗死快速診斷的依據。

      【參考文獻】

      [1]陳揚清.肌鈣蛋白 I、肌紅蛋白、肌酸激酶同工酶三合一檢測的臨床意義[J].醫學美學美容(中旬刊),2014(2):106-107.

      [2]王海紅,黃記兵,王海光等.肌鈣蛋白I、肌紅蛋白、肌酸激酶同工酶三合一試劑在急性心肌梗死早期診斷中的應用[J].檢驗醫學與臨床,2010,7(15):1629-1630.

      [3]周艷麗,章靜,王淑春等.床旁快速聯合測定肌鈣蛋白 I、肌酸激酶同工酶和肌紅蛋白診斷急性心肌梗死的臨床價值[J].檢驗醫學與臨床,2015(21):3224-3226.

      [4]付英姿,安剛,呂紅君等.肌鈣蛋白I、肌酸激酶同工酶、肌紅蛋白檢測對急性冠脈綜合征的診斷價值[J].中國老年學雜志,2015(15):4221-4223.

      [5]陳影芳,吳堅洪,梁宇亨等.肌鈣蛋白I、肌紅蛋白、N-末端B型尿鈉肽前體和肌酸激酶同工酶在心肌梗死早期診斷中的應用[J].包頭醫學院學報,2015,31(11):82-83.

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